Table 1.
Baseline patient demographics based on 6 patient groups undergoing cessation of anti-platelet therapy, with a further group receiving uninterrupted DAPT.
| Entire cohort |
Permanent d/c Aspirin + Clopidogrel |
Temporary d/c Aspirin + Clopidogrel |
Permanent d/c Aspirin |
Temporary d/c Aspirin |
Permanent d/c Clopidogrel |
Temporary d/c Clopidogrel |
Uninterrupted DAPT |
p value | |
|---|---|---|---|---|---|---|---|---|---|
| N | 5681 | 118 | 331 | 187 | 54 | 713 | 208 | 4070 | |
| Age (years) | 66 ± 11 | 68 ± 12 | 66 ± 10 | 69 ± 11 | 68 ± 11 | 67 ± 11 | 66 ± 11 | 65 ± 12 | <0.0001 |
| Male gender (%) | 67 | 69 | 63 | 61 | 56 | 62 | 72 | 68 | 0.032 |
| Hypertension (%) | 88 | 86 | 88 | 86 | 90 | 87 | 89 | 84 | 0.021 |
| Diabetes (%) | 38 | 39 | 32 | 30 | 37 | 27 | 35 | 41 | <0.0001 |
| Hyperlipidemia (%) | 88 | 86 | 90 | 86 | 89 | 84 | 90 | 89 | 0.0012 |
| Current smoker (%) | 18 | 22 | 17 | 17 | 15 | 15 | 18 | 15 | 0.43 |
| Previous CABG (%) | 15 | 14 | 15 | 9 | 13 | 10 | 15 | 16 | 0.0041 |
| Chronic renal impairment (%) |
11 | 11 | 11 | 15 | 6 | 7 | 10 | 11 | 0.012 |
| LVEF (%) | 54 ± 9 | 54 ± 10 | 54 ± 10 | 53 ± 11 | 54 ± 10 | 55 ± 8 | 54 ± 10 | 54 ± 10 | 0.22 |
| Receiving Coumadin (%) |
5 | 13 | 4 | 12 | 9 | 6 | 3 | 4 | <0.0001 |
| Presenting syndrome | 0.19 | ||||||||
| Stable angina (%) | 57 | 64 | 63 | 57 | 58 | 61 | 56 | 56 | |
| Unstable angina (%) | 34 | 28 | 30 | 30 | 36 | 30 | 36 | 35 | |
| AMI (%) | 9 | 8 | 7 | 13 | 6 | 9 | 8 | 9 |
P value represents results of Pearson’s chi-square test or ANOVA for overall differences among groups. d/c discontinuation; LVEF = left ventricular ejection fraction.