Effect of hypercapnia (ΔpH = 0.5) and warming (+4°C) on the: (a,b) PVF pO2 (kPa, n = 20), (c,d) measured external (ambient) critical partial pressure (Pc,ext, kPa; n = 20), (e,f) estimated internal critical partial pressure (Pc,in, kPa; n = 20), and (g,h) difference between mean values of PVF pO2 and Pc,in (kPa), of intermediate embryonic stages (a,c,e,g) and pre-hatchlings (b,d,f,h) of common cuttlefish Sepia officinalis. Values represent the mean ± s.d. Different letters represent significant differences between treatments (p < 0.05). Asterisks represent significant differences between life stages (p < 0.05).