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. 2011 Dec;17(6):645–658. doi: 10.1177/1073858411385469

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© SAGE Publications 2011

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Inferior olivary degeneration in a patient harboring the m.8344A>G mutation. (A) Severe neuronal cell loss from the inferior olivary nucleus (hematoxylin and eosin stain). (B) High mitochondrial density within remaining inferior olivary neurons (antiporin immunohistochemistry). (C) Complex I–deficient neuron (arrow) evident in the inferior olivary nucleus (anti–complex I subunit 20 kDa immunohistochemistry). (D) Absence of complex IV subunit I expression in the inferior olivary neurons (anti-COXI immunohistochemistry). Scale bar represents 100 µm.