Figure 3.

Four types of three-dimensional artificial deformations were applied to a baseline OCT volume using an inverse mapping technique. The same slice (slice no. 49 which is the middle slice) is shown for all volumes before (baseline) and after application of the artificial deformations. Case 1 represents a three-dimensional rigid body motion (tilting can be observed in the image). Case 2 represents radial expansion of the volume to mimic the effects of increased IOP (dashed lines emphasize the observed expansion of the scleral canal). Case 3 represents radial expansion together with tissue thinning in the radial direction to mimic the compression effects of increased IOP (dashed lines also indicate the expansion of the scleral canal). Case 4 represents radial expansion together with nonlinear tissue thinning to mimic higher thinning in the softer ocular layers (retinal, choroid and pre-laminar tissue), and posterior lamina cribrosa bowing as often observed in vivo [23]. Note that the deformations appear small but are consistent with those expected to occur in vivo.