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. 2013 Mar 16;5(1):13–17. doi: 10.1016/j.jyp.2013.02.001

Table 2.

Average plasma concentration of warfarin, 7-hydroxy warfarin and metabolic ratio at different dose groups.

Warfarin dose group n = 178 Plasma warfarin (μg/ml) Plasma 7-OH warfarin (μg/ml) Metabolic ratio (MR)
  • A

    Low dose group [≤2.5 mg/day]

 35 2.88 ± 1.46 [2.2–3.5] 1.53 ± 1.12 [1.0–2.0] 2.56 ± 1.48 [1.93–3.18]
  • B

    Standard dose group [≥2.5 to ≤8.5 mg/day]

 138 3.53 ± 1.89 [3.1–3.9] 1.19 ± 0.7 [1.0–1.3] 3.72 ± 2.66 [3.17–4.28]
  • C

    High dose group [≥8.5 mg/day]

 5 6.38 ± 1.58 [2.4–10.3] 0.97 ± 0.46 [0.18–2.1] 7.43 ± 2.74 [0.7–14.19]

Values expressed as – [mean ± SD (95% Confidence interval)].

Metabolic ratio – Plasma concentrations of warfarin/7-hydroxy warfarin.

MR – A vs B p < 0.05, B vs C p > 0.05, A vs C p < 0.05.