Table 5.

Effect of Docosahexaenoic Acid (DHA) Intake on Progression to Geographic Atrophy According to Risk/Non-Risk Genotypes

	5th Quintile DHA vs 1st Quintile DH A
	Model A*			Model B ‡
	HR (95% CI)	P Value	P Value (Interaction)	HR (95% CI)	P Value	P Value (Interaction)
Gene (homozygous risk/homozygous non-risk)
CFH : rs1061170 (Y402H)
T T	0.5 (0.3 – 0.8)	0.01		0.5 (0.3 – 0.9)	0.02
C C	0.9 (0.6 – 1.3)	0.52	0.10	0.8 (0.6 – 1.2)	0.37	0.16
CFH : rs1410996
T T	0.4 (0.2 – 1.0)	0.05		0.4 (0.2 – 1.0)	0.05
C C	0.8 (0.6 – 1.1)	0.22	0.18	0.8 (0.6 – 1.1)	0.12	0.20
ARMS2/HTRA1 : rs10490924 (A69S)
G G	1.0 (0.6 – 1.6)	0.99		1.0 (0.6 – 1.6)	0.90
T T	0.5 (0.3 – 0.8)	0.004	0.06	0.4 (0.3 – 0.7)	0.002	0.05
C2 : rs9337239 (E318D) †
GG	0.7 (0.6 – 1.0)	0.04		0.7 (0.5 – 0.9)	0.02
CG/CC	0.05(0.0 – 15.6)	0.30	0.36	0.03 (0.0 – 10.8)	0.25	0.30
CFB : rs641153 (R32Q) †
C C	0.7 (0.5 – 0.9)	0.02		0.7 (0.5 – 0.9)	0.01
C T/T T	1.6 (0.2 – 11.1)	0.64	0.42	1.9 (0.3 – 12.3)	0.52	0.30
C3 : rs2230199 (R102G)
CC	0.7 (0.5 – 1.1)	0.15		0.7 (0.5 – 1.1)	0.14
GG	0.7 (0.3 – 1.3)	0.26	0.84	0.6 (0.3 – 1.2)	0.17	0.16
CFI : rs10033900
C C	0.6 (0.3 – 1.0)	0.07		0.6 (0.3 – 1.0)	0.06
T T	0.9 (0.5 – 1.3)	0.49	0.40	0.8 (0.5 – 1.2)	0.29	0.49
LIPC :rs10468017
C C	0.7 (0.5 – 1.0)	0.05		0.7 (0.5 – 1.0)	0.03
T T	0.8 (0.4 – 1.8)	0.64	0.72	0.7 (0.3 – 1.6)	0.40	0.91

HR = Hazard Ratio; CI = Confidence Interval

^*Model A = adjusted for single gene, DHA, baseline grade, demographic and environmental characteristics: age, gender, education, smoking, antioxidants, and body mass index.

^‡Model B= adjusted for covariates in Model A + all genes shown in Table 3.

^†Heterozygous genotype combined with homozygous risk due to small numbers.