Figure 1.

Selective impact of MCI on intrinsic brain networks. (a) Patterns reflecting areas of significant intrinsic functional connectivity (iFC) of resting-state fMRI activity (blood oxygenation level-dependent signal, one-sample t-test, p < 0.05 FDR corrected). In the first row, the pattern reflects the default mode network (DMN), the pattern in the second row reflects a bilateral attention network (ATN), (i) data derived from 16 healthy elderly, (ii) data from 24 patients with MCI, (iii) corresponding glass brain projection for all subjects). (b) (i), pattern of reduced iFC in the DMN of patients, (ii), reduced iFC in the ATN of patients (two-sample t-test, p < 0.05 FDR-corrected). (Adapted from Buckner et al. [24].) (Online version in colour.)