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. Author manuscript; available in PMC: 2013 Aug 30.

Published in final edited form as: J Nucl Med. 2009 Jul 17;50(8):1356–1363. doi: 10.2967/jnumed.108.060822

Representative microSPECT-CT images of wild-type (eNOS+/+) and eNOS-knockout (eNOS-/-) mice injected with ^99mTc-NC100692 at baseline, 7 days, and 4 weeks post right femoral artery ligation (A). Yellow arrows indicate ischemic regions with increased ^99mTc-NC100692 retention. Less retention is seen in eNOS-/- mice. Serial microSPECT-CT images were analyzed and I/N ^99mTc-NC100692 activity ratios calculated (B). There was a significant (P<0.05) increase of ^99mTc-NC100692 retention in ischemic leg at 7 days post surgery in both groups. However, there was significantly less retention in the eNOS-/- mice at 7 days compared with wild-type mice.

* P < 0.05 vs. wild-type

# P < 0.05 vs. baseline

Representative microSPECT-CT images of wild-type (eNOS+/+) and eNOS-knockout (eNOS-/-) mice injected with ^99mTc-NC100692 at baseline, 7 days, and 4 weeks post right femoral artery ligation (A). Yellow arrows indicate ischemic regions with increased ^99mTc-NC100692 retention. Less retention is seen in eNOS-/- mice. Serial microSPECT-CT images were analyzed and I/N ^99mTc-NC100692 activity ratios calculated (B). There was a significant (P<0.05) increase of ^99mTc-NC100692 retention in ischemic leg at 7 days post surgery in both groups. However, there was significantly less retention in the eNOS-/- mice at 7 days compared with wild-type mice.

* P < 0.05 vs. wild-type

# P < 0.05 vs. baseline