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. 2013 Aug 30;8(8):e72989. doi: 10.1371/journal.pone.0072989

Figure 6. ISO-092 does not block diabetes induction in MAD rats.

Figure 6

Male and female MAD (LEW.1WR1) rats (n=10/group) 21-25 days of age on Day -3 were induced for T1D with poly (I:C) on Days -3, -2, and -1 and infected with KRV on Day 1 (clear bar). ISO-092 or vehicle was administered via ALZET osmotic pump beginning of Day -1 (hashed bar). A positive control group was administered dexamethasone once daily by IP injection on Days 6-10 (checkered bar, p = 0.0006, vehicle vs. dexamethasone, Log-rank [Mantel-Cox] test).