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. 2013 Aug 30;8(8):e74116. doi: 10.1371/journal.pone.0074116

Figure 3. Changes in heart function with age.

Figure 3

A. In WT, ejection fraction decreases with age and is significantly reduced in 2 yr old WT compared to 2 mo. Ejection fraction in D3KO is significantly reduced from age-matched WT and is comparable to that of the 2 yr old WT. B. In WT, fractional shortening decreases with age and is significantly reduced in the 2 yr old WT versus 2 mo old WT. Note that D3KO fractional shortening is significantly reduced from age-matched WT but similar to that of the 2 yr old WT. C. Stroke volume peaks in WT at 1 yr before returning at 2 yrs to similar values as in 2 mo old WT. In D3KO stroke volume is significantly decreased over age-matched WT controls. D. Similar to stroke volume, cardiac output in WT significantly increases from 2 mo to 1 year before declining at 2 yrs of age. In D3KO cardiac output is significantly reduced compared to 1 yr old WT (p<0.001, ANOVA), or when solely compared to age-matched WT controls (p = 0.04, t-test).