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. 2013 Aug 30;8(8):e73062. doi: 10.1371/journal.pone.0073062

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© 2013 Karch et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative photomicrographs showing two LCIS lesions characterized by either similar (left, case #1) or reduced (right, case #10) BCL2 immunoreactivity compared with the adjacent E-cadherin-positive epithelium. HE stained sections are shown on top. Serial sections subjected to immunohistochemical staining of E-cadherin (Ecad) and BCL2 are shown below. (B) Overview on BCL2 immunoreactivity in LCIS lesions of n = 11 patients. At least three TDLUs affected by LCIS were considered per case, but showed essentially the same staining characteristics (not shown). A color scale indicative of the IRS is included on the right side.