Table 1. Effect of concomitant administration of cycloart-23-ene-3β, 25 diol and L-glutamine with sitagliptin on body weight, food and water intake in streptozotocin – nicotinamide induced diabetic rats.
| Parameters | Non-diabetic | Diabetic control | Cycloart-23-ene-3β, 25 diol(1 mg/kg) + Sitagliptin (5 mg/kg) | L-glutamine (1000 mg/kg)+Sita (5 mg/kg) | ||
| Body weight (g/day) | 0 | 198.83±5.83 | 208.20±6.82 | 208.74±2.32 | 201.32±2.43 | |
| Week 1 | 206.83±4.57 | 205.00±6.73 | 209.19±3.65 | 202.87±3.76 | ||
| Week 2 | 213.50±5.73 | 196.40±6.97 | 205.32±4.19 | 200.62±6.18 | ||
| Week 3 | 223.83±5.9 | 190.20±9.02# | 213.31±5.38* | 197.75±3.38 | ||
| Week 4 | 236.66±7.62 | 174.40±5.77# | 212.96±6.27** | 198.00±5.42 | ||
| Week 5 | 245.00±7.60 | 169.00±4.78# | 215.02±5.38** | 197.14±2.63* | ||
| Week 6 | 252.33±7.27 | 169.20±3.99# | 218.59±6.12*** | 197.50±4.74* | ||
| Week 7 | 265.33±8.27 | 163.00±3.46# | 219.63±4.91*** | 196.83±6.43** | ||
| Week 8 | 284.50±5.78 | 160.00±3.11# | 225.46±6.23*** | 195.49±6.40*** | ||
| Food intake (g/day) | 0 | 16.78±0.69 | 26.15±0.55# | 26.37±0.64 | 26.43±0.53 | |
| Week 1 | 18.31±0.57 | 26.66±0.42# | 25.03±0.53 | 26.19±0.69 | ||
| Week 2 | 18.48±0.58 | 28.16±0.70# | 22.32±0.79 | 25.65±0.50 | ||
| Week 3 | 19.84±0.97 | 30.50±0.62# | 22.09±0.71 | 25.13±0.81*** | ||
| Week 4 | 19.34±0.34 | 33.66±0.75# | 23.93±0.83 | 24.07±0.71*** | ||
| Week 5 | 19.68±0.36 | 34.37±0.42# | 23.18±0.61 | 24.09±0.69*** | ||
| Week 6 | 19.80±0.76 | 38.13±0.68# | 23.73±0.79 | 23.49±0.30*** | ||
| Week 7 | 18.50±0.64 | 37.16±0.60# | 22.07±0.68 | 23.45±0.47*** | ||
| Week 8 | 19.80±0.44 | 39.08±0.73# | 21.17±0.49 | 23.05±0.61*** | ||
| Water Intake ml/day) | 0 | 21.83±0.60 | 69.50±2.33# | 72.07±2.27 | 71.73±1.82 | |
| Week 1 | 22.50±0.49 | 69.83±1.95# | 65.71±2.43 | 69.54±2.19 | ||
| Week 2 | 22.61±0.51 | 71.00±1.75# | 53.79±3.18 | 61.16±4.19** | ||
| Week 3 | 22.83±0.70 | 79.66±2.33# | 47.31±2.69 | 49.50±3.14*** | ||
| Week 4 | 22.33±0.61 | 82.33±2.37# | 34.09±2.91 | 41.71±3.11*** | ||
| Week 5 | 22.05±0.53 | 90.00±3.58# | 28.93±1.79 | 32.20±2.38*** | ||
| Week 6 | 21.16±0.47 | 103.33±2.45# | 22.86±1.95 | 26.16±3.13*** | ||
| Week 7 | 22.24±0.3 | 108.43±3.71# | 22.48±2.39 | 25.09±2.17*** | ||
| Week 8 | 22.37±0.58 | 116.43±2.04# | 21.91±2.04 | 23.74±1.06*** | ||
Values are mean ± S.E.M., n = 6 in each group; statistical analysis by one way ANOVA followed by Post hoc Tukey’s test using Graphpad Instat software; p value #<0.001 compared to non-diabetic groups;
*
<0.05;
**
<0.01;
***
<0.001 compared to diabetic control group.