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. 2013 Aug 30;8(8):e72790. doi: 10.1371/journal.pone.0072790

Figure 5. ADSCs -VEGF increased the expression of VEGF, its two receptors, and eNOS in STZ-induced diabetic rats.

Figure 5

Expression of VEGF, its receptors VEGF R1 and VEGF R2, and eNOS increased in STZ-induced rats 4 weeks after ADSCs with or without VEGF or lentivirus-VEGF alone confirmed by immunofluorescence staining (white arrow represents specific staining) (A), Western blotting (B), and quantitative analysis for Western blotting (C). Expression was higher in the ADSCs-VEGF treatment group than with ADSCs or VEGF treatment, but no difference between ADSCs and lentivirus-VEGF treatment (A–C). VEGF, VEGFR1, VEGFR2 and eNOS expression were greater at 28 days after all three treatments than in 7 days (B, C). Scale bar = 50 µm; *p<0.05, **p<0.01.