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. 2013 Aug 30;8(8):e74247. doi: 10.1371/journal.pone.0074247

Figure 1. A low dose of insulin for 4 to 5 weeks normalizes impaired thermal (a) and mechanical (b) perception in diabetic rats.

Figure 1

Nociceptive responses to thermal and mechanical stimuli are expressed as tail-flick latency (seconds) and paw-pressure withdrawal threshold (grams), respectively, in control (white squares), untreated STZ-induced diabetic (black squares) and insulin-treated STZ-induced diabetic (black triangles) rats. Data are means ± SE of 11 control, 9 to 10 untreated STZ-induced diabetic and 11 insulin-treated STZ-induced diabetic rats for tail-flick latency, and of 8 to 10 control, 10 untreated STZ-induced diabetic, and 10 to 11 insulin-treated STZ-induced diabetic rats for paw-pressure withdrawal threshold measurements. * p = 0.05, † p<0.05, and ‡ p<0.001 vs. control rats; § p = 0.05 and ** p<0.0005 vs. untreated STZ-induced diabetic rats.