Table 1.

Baseline characteristics of selected trials of blood purification in sepsis

Source	Country of origin	No. of Patients	Mean Age (years)	Male (%)	Center	Mean APACHE II/III/ SAPS II/ SOFA score	Diagnosis	Jadad Score*
Huang, 2010(23)	China	44	74.9	45.5	S	APACHE II: 28.8 SOFA: 7.6	Severe sepsis or septic shock†	2
Peng, 2010(9)	China	22	53.4	59.1	S	APACHE II:18.6	Severe sepsis†	2
Cruz, 2009(24)	Italy	64	64	65.5	M	APACHE II: 20.5 SOFA: 10	Severe sepsis or septic shock†	5
Payen, 2009(25)	France	76	58.1	74.4	M	SAPS II: 53.4 SOFA:11	Severe sepsis or septic shock†	2
Peng, 2005(26)	China	20	33.2	95	S	N/A	Sepsis†	1
Vincent, 2005(27)	Belgium	35	57.5	63	M	APACHE II: 17.7 SOFA:10.1	Severe sepsis or septic shock†	4
Reinhart, 2004(28)	Germany	143	61.2	62.2	M	APACHE II:28 SOFA:11.8	Severe sepsis or septic shock†	4
Nakamura, 2004(29)	Japan	25	60	75	S	APACHE II:28.2	Severe sepsis†	3
Nakamura, 2003(30)	Japan	20	63.7	60	S	APACHE II:27.3	Sepsis†	2
Nakamura, 2003(31)	Japan	60	55.5	66.7	S	APACHE II:23.5	Sepsis†	4
Busund, 2002(32)	Norway	106	44	56.6	S	APACHE III: 54.9	Severe sepsis or septic shock†	2
Nakamura, 2002(33)	Japan	18	40	66.7	S	APACHE II: 28	Sepsis†	3
Cole, 2002(17)	Australia	24	66.8	58.3	S	APACHE II: 22 SAPS II: 45	Septic shock or septic organ dysfunction†	5
Nemoto, 2001(34)	Japan	98	62	61.2	S	APACHE II: 22.5	Sepsis, severe sepsis or septic shock†	2
Reeves, 1999(35)	Australia	22	59.4	63.6	M	APACHE II: 25.2	Sepsis††	2
Nakamura, 1999(36)	Japan	50	53.8	60	M	APACHE II: 24.8	Septic shock††	1

APACHE, acute physiology and chronic health evaluation; SAPS, simplified acute physiology score; SOFA, sequential organ failure assessment; S, single center trial; M, multicenter trial; N/A, not applicable.

^*Jadad score was calculated using investigator-blinding in place of double-blind design.

^†Patients were diagnosed according to the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference criteria;

^††Patients were diagnosed according to the other criteria.