Table 1.
Repeatedly hit genes are putative drivers of adaptation
| Gene | Hits | Fixed | Biological process* |
|---|---|---|---|
| IRA1 | 21 | 10 | Negative regulator of Ras |
| ROT2 | 11 | 2 | Cell wall biogenesis |
| YUR1 | 11 | 5 | Cell wall biogenesis |
| ACE2 | 9 | 4 | Cytokinesis |
| STE11 | 9 | 1 | Mating |
| STE12 | 9 | 2 | Mating |
| PDR5 | 8 | 5 | Multidrug transport |
| WHI2 | 7 | 2 | General stress response |
| STE4 | 6 | 1 | Mating |
| IRA2 | 5 | 3 | Negative regulator of Ras |
| KRE6 | 4 | 1 | Cell wall assembly |
| SFL1 | 4 | 1 | Regulation of flocculation genes |
| STE5 | 4 | 3 | Mating |
| ANP1 | 3 | 1 | Protein glysosylation |
| CNE1 | 3 | 2 | Protein folding |
| GAS1 | 3 | 3 | Cell wall assembly |
| GCN1 | 3 | 1 | Regulation of translation |
| GPB1 | 3 | 1 | Negative regulator of Ras |
| GPB2 | 3 | 1 | Negative regulator of Ras |
| KEG1 | 3 | 0 | Cell wall assembly |
| KRE5 | 3 | 1 | Cell wall assembly |
| RPO31 | 3 | 0 | RNA ploymerase III transcription |
| SET4 | 3 | 2 | unknown |
| YJL171C | 3 | 0 | unknown |
*
Biological process was manually curated from the Saccharomyces Genome Database (www.yeastgenome.org).