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. Author manuscript; available in PMC: 2014 Feb 28.
Published in final edited form as: Nat Genet. 2013 Jul 28;45(9):1004–1012. doi: 10.1038/ng.2715

Figure 1. Concomitant ablation of cilia ameliorates progression of ADPKD.

Figure 1

Double inactivation of cilia and polycystins reduces cyst formation irrespective of the polycystin gene involved (Pkd1, a-d, Pkd2, e-h), the gene targeted for cilia ablation (Kif3a, a-d, Ift20, e-h). Representative images (a, e) and aggregate quantitative data (b, f) of kidney-to-body weight ratio, percent cystic area (cystic index) and serum urea nitrogen with the indicated genotypes. Immunohistochemistry showing (c, g) absence of cilia in cilia-polycystin double mutants and (d, h) presence of cilia in polycystin-only single mutants. Mice were examined at P24. Arrows indicate cilia. The color squares represent the respective genotypes in the histograms. The numbers of animals (n) in each group are indicated below the histogram bars. Multiple group comparisons were performed using one-way ANOVA followed by Tukey’s multiple comparison test and are presented as the mean ± SEM (***, P<0.001; **, P<0.01; *, P<0.05). Scale bar, 2 mm for a, e; 20 μm for c, d, g, h.