Table 2.
Unadjusted bivariable analysis and multivariable logistic regression models evaluating the association between alcohol use and absence of liver fibrosis [FIB-4 <1.45 and APRI <0.5]
| Variable | Unadjusted OR (95% CI) for FIB-4 <1.45 |
p- value |
Adjusted OR (95% CI) for FIB-4 <1.45 |
p- value |
Unadjusted OR (95% CI) for APRI <0.5 |
p-value | Adjusted OR (95% CI) for APRI <0.5 |
p- value |
|---|---|---|---|---|---|---|---|---|
| Model 1 | ||||||||
| Lifetime alcohol consumption [kg of alcohol] (n=272) |
||||||||
| <150 kg | 1 | 0.59 | 1 | 0.95 | 1 | 0.4 | 1 | 0.52 |
| 150–600 kg | 0.77 (0.40, 1.48) | 1.12 (0.52, 2.52) | 1.30 (0.68, 2.47) | 1.36 (0.64, 2.90) | ||||
| >600 kg | 0.73 (0.39, 1.36) | 1.11 (0.52, 2.36) | 0.90 (0.49, 1.63) | 0.96 (0.47, 1.93) | ||||
| Sex: | ||||||||
| Female | 1.02 (0.52, 2.02) | 0.95 | 0.94 (0.50, 1.77) | 0.85 | ||||
| Male | 1 | 1 | ||||||
| HCV infection (HCV RNA) |
0.29 (0.16, 0.52) | <0.01 | 0.16 (0.09, 0.28) | <0.01 | ||||
| CD4 count [cells/mm3] | * | |||||||
| <200 | 0.30 (0.14, 0.67) | <0.01 | 0.56 (0.26, 1.20) | 0.26 | ||||
| 200–500 | 0.44 (0.23, 0.82) | <0.01 | 0.69 (0.38, 1.26) | |||||
| >500 | 1 | 1 | ||||||
| Age [per additional year] | 0.89 (0.85, 0.93) | <0.01 | 1.00 (0.96, 1.04) | 0.98 | ||||
| Model 2 | ||||||||
| Heavy episodic drinking (n=282) |
||||||||
| <9 years | 1 | 0.21 | 1 | 0.42 | 1 | 0.52 | 1 | 0.99 |
| 9–21 years | 1.55 (0.88, 2.71) | 1.37 (0.70, 2.68) | 1.29 (0.74, 2.24) | 0.99 (0.52, 1.87) | ||||
| >21 years | 1.01 (0.56, 1.81) | 1.58 (0.78, 3.71) | 0.97 (0.54, 1.73) | 1.02 (0.52, 2.00) | ||||
| Sex | ||||||||
| Female | 0.94 (0.49, 1.80) | 0.85 | 0.98 (0.53, 1.82) | 0.95 | ||||
| Male | 1 | 1 | ||||||
| HCV infection (HCV RNA) |
0.33 (0.19, 0.58) | <0.01 | 0.17 (0.10, 0.28) | <0.01 | ||||
| CD4 count [cells/mm3] | * | |||||||
| <200 | 0.32 (0.15, 0.70) | <0.01 | 0.57 (0.27, 1.21) | 0.25 | ||||
| 200–500 | 0.40 (0.22, 0.74) | <0.01 | 0.67 (0.38, 1.21) | |||||
| >500 | 1 | 1 | ||||||
| Age [per additional year] | 0.89 (0.85, 0.93) | <0.01 | 0.99 (0.96, 1.03) | 0.75 | ||||
| Model 3 | ||||||||
| Heavy alcohol use [NIAAA definition] (last 30 days) (n=286) |
0.99 (0.61, 1.61) | 0.96 | 0.89 (0.50, 1.58) | 0.69 | 0.82 (0.51, 1.33) | 0.43 | 0.86 (0.49, 1.50) | 0.59 |
| Sex: | ||||||||
| Female | 0.99 (0.52, 1.89) | 0.97 | 1.02 (0.55, 1.88) | 0.95 | ||||
| Male | 1 | 1 | ||||||
| HCV infection (HCV RNA) |
0.31 (0.18, 0.54) | <0.01 | 0.16 (0.09, 0.27) | <0.01 | ||||
| CD4 count [cells/mm3] | * | |||||||
| <200 | 0.31 (0.14, 0.67) | <0.01 | 0.55 (0.26, 1.16) | 0.23 | ||||
| 200–500 | 0.40 (0.22, 0.74) | <0.01 | 0.68 (0.38, 1.22) | |||||
| >500 | 1 | 1 | ||||||
| Age [per additional year] | 0.89 (0.86, 0.93) | <0.01 | 0.99 (0.96, 1.03) | 0.68 | ||||
HCV RNA: Hepatitis C virus Ribonucleic acid;
*
global p-value <0.05; OR (95% CI): Odds ratio (95% Confidence interval).