. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Alcohol Clin Exp Res. 2013 May 3;37(9):1527–1535. doi: 10.1111/acer.12129

Table 3.

Unadjusted bivariable analysis and multivariable logistic regression models evaluating the association between alcohol use and advanced liver fibrosis [FIB-4 >3.25 and APRI >1.5].

Variable	Unadjusted OR (95% CI) for FIB-4 >3.25	p- value	Adjusted OR (95% CI) for FIB- 4 >3.25	p- value	Unadjusted OR (95% CI) for APRI >1.5	p-value	Adjusted OR (95% CI) for APRI >1.5	p- value

Model 1

Lifetime alcohol consumption [kg of alcohol] (n=272)
<150 kg	1	0.41	1	0.11	1	0.57	1	0.39
150–600 kg	0.49 (0.17, 1.40)		0.27 (0.07, 0.98)		0.56 (0.18, 1.75)		0.42 (0.12, 1.53)
>600 kg	0.69 (0.28, 1.70)		0.64 (0.23, 1.81)		0.84 (0.31, 2.23)		0.76 (0.26, 2.19)

Sex:
Female			2.38 (0.91, 6.19)	0.08			0.54 (0.17,1.75)	0.31
Male			1				1

HCV infection (HCV RNA)			3.39 (1.17, 9.78)	0.02			5.16 (1.66, 16.06)	<0.01

CD4 count [cells/mm³]				^*				^*
<200			12.75 (2.45, 66.38)	<0.01			6.65 (1.61, 27.45)	<0.01
200–500			7.54 (1.62, 35.04)	<0.01			3.55 (0.95, 13.30)	0.06
>500			1				1

Age [per additional year]			1.08 (1.01, 1.15)	0.02			1.04 (0.98, 1.11)	0.24

Model 2

Heavy episodic drinking (n=282)
<9 years	1	0.66	1	0.39	1	0.89	1	0.61
9–21 years	0.86 (0.36, 2.05)		1.28 (0.46, 3.51)		0.98 (0.39, 2.47)		1.25 (0.45, 3.47)
>21 years	0.64 (0.24, 1.72)		0.61 (0.21, 1.81)		0.80 (0.28, 2.24)		0.72 (0.24, 2.17)

Sex
Female			1.98 (0.79, 4.69)	0.14			0.45 (0.14, 1.43)	0.18
Male			1				1

HCV infection (HCV RNA)			4.18 (1.46, 11.92)	<0.01			6.41 (2.07, 19.80)	<0.01

CD4 count [cells/mm³]				^*				^*
<200			10.20 (1.99, 52.24)	<0.01			6.00 (1.47, 24.48)	0.01
200–500			8.27 (1.81, 37.92)	<0.01			4.07 (1.11, 14.94)	0.03
>500			1				1

Age [per additional year]			1.07 (1.01, 1.14)	0.02			1.04 (0.98, 1.10)	0.24

Model 3

Heavy alcohol use [NIAAA definition] (last 30 days) (n=286)	0.97 (0.44, 2.14)	0.94	1.10 (0.45, 2.65)	0.84	1.15 (0.51, 2.59)	0.74	1.14 (0.47, 2.77)	0.77

Sex:
Female			1.85 (0.75, 4.55)	0.18			0.44 (0.14, 1.37)	0.15
Male			1				1

HCV infection (HCV RNA)			4.35 (1.55, 12.19)	<0.01			6.55 (2.15, 19.97)	<0.01

CD4 count [cells/mm³]				^*				^*
<200			10.95 (2.20, 54.41)	<0.01			6.61 (1.65, 26.49)	0.03
200–500			7.90 (1.73, 35.95)	<0.01			4.07 (1.11, 14.93)	<0.01
>500			1				1

Age [per additional year]			1.06 (1.00, 1.13)	<0.05			1.03 (0.97, 1.10)	0.33

HCV RNA: Hepatitis C virus Ribonucleic acid;

global p-value <0.05; OR (95% CI): Odds ratio (95% Confidence interval).