Table 2.
Physiological effects of chronic variable stress:
| Males | Females | |||||||
|---|---|---|---|---|---|---|---|---|
| Throughout CVS treatment: | ||||||||
| Treatment | Day | Control | Pair-fed | PAE | Control | Pair-fed | PAE | |
|
% change in Body Weight (g) |
Non-CVS |
1–5 5–10 |
3.9±0.4 a 9.8±0.4 a |
4.7±0.5 a 11.4±0.8 a |
6.0±0.8 a 12.3±1.4 a |
1.6±0.5a 7.9±0.7a |
2.8±0.5a 7.6±0.9a |
5.1±1.7a 7.0±0.6a |
| CVS |
1–5 5–10 |
0.4±0.5 2.5±0.8 |
0.7±0.5 2.4±0.8 |
0.0±0.5 0.4±1.6 b |
−1.4±0.6 −0.5±1.3 |
−2.8±0.6 −1.9±1.0 |
−2.4±0.5 −5.2±1.3 b |
|
|
Basal CORT (ng/mL) |
CVS |
1 5 10 |
0.9±0.3 1.3±0.4 1.3±0.6 |
0.8±0.2 0.7±0.0 0.9±0.2 |
0.7±0.1 1.4±0.4 0.8±0.1 |
0.75±0.1 12.4±6.2 2.9±1.6 |
1.8±0.4 8.1±3.4 3.3±1.9 |
2.7±1.6 c 4.3±2.4c 5.7±2.1 c |
| 24 hours post-CVS treatment: | ||||||||
|
Basal CORT (ng/mL) |
Non-CVS | - | 1.1±0.3 | 2.1±1.1 | 1.3±0.4 | 6.1±1.4 | 2.8±0.9 | 3.7±0/9 |
| CVS | - | 2.0±0.5 | 2.2±0.7 | 2.1±0.4 | 3.2±1.0 | 5.0±1.9 | 3.7±1.4 | |
|
Basal T (ng/mL) |
Non-CVS | - | 1.9±0.4 | 2.9±0.6 | 1.2±0.2d | - | - | - |
| CVS | - | 2.4±0.6 | 2.0±0.2 | 1.5±0.2d | - | - | - | |
|
Basal E2 (pg/mL) |
Non-CVS | - | - | - | - | 102±39 | 144±73 | 59±16 |
| CVS | - | - | - | - | 28±13 | 121±42 | 57±21 | |
|
Basal P4 (ng/mL) |
Non-CVS CVS |
- | - | - | - | 85±26 | 51±16 | 84±18 |
| - | - | - | - | 38±12e | 45±13e | 44±6e | ||
Summary of physiological effects of CVS: 1) Throughout CVS on days 1, 5 and 10; and 2) 24 hrs following the last day of CVS (or non-CVS). Mean ±SEM.
a
Non-CVS > CVS overall, p<0.001;
b
PAE<C, p<0.001);
c
C>PAE overall, p<0.05;
d
C=PF>PAE overall, p’s<0.05;
e
Non-CVS>CVS overall, p<0.05.
Abbreviations: CVS, chronic variable stress; g, grams; CORT, corticosterone; T, testosterone; E2, estradiol; P4, progesterone.