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. Author manuscript; available in PMC: 2013 Aug 30.
Published in final edited form as: Nat Rev Genet. 2008 Oct;9(10):764–775. doi: 10.1038/nrg2430

Figure 5. Circadian control of cell division cycles.

Figure 5

Circadian system is linked to the cell division cycle via circadian control of gene expression and posttranslational mechanisms. The transcription of c-Myc and Wee1 is circadian and appears to be a direct target of the CLOCK:BMAL1. The expression of Wee1 is co-regulated with Per and the entry of the cell cycle into M phase is suppressed during the day time when the transcription of Per (and Wee1) is high. In addition, the PER1 protein interacts with the check-point proteins, ATM and Chk2; while related work has linked the TIMELESS (TIM) and CRY proteins with Chk1. Activation of the DNA damage pathway can also reset the phase of the circadian clock.