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. 2011 Feb 2;31(5):1664–1675. doi: 10.1523/JNEUROSCI.3829-10.2011

Figure 10.

Figure 10.

GD1a/GT1b-2b mAbs induce repulsive growth cone turning response. A, Xenopus spinal neuron growth cone staining with phalloidin (actin; red) and GD1a/GT1b-2b (green) shows that these neurons express ganglioside moieties. Scale bar, 5 μm. B, Growth cone turning responses to a gradient of GD1a/GT1b-2b mAb in the pipette (at top right corner) at the start (0 min) and end (30 min) of exposure. Superimposed trajectories of neurite extension during this period for a sample of 10 neurons are shown on the right. Scale bars: 20 and 10 μm in left two and right panels, respectively. C, Significant growth cone chemorepulsion with gradients of MAG and GD1a/GT1b-2b mAb compared with heat- inactivated MAG. *p < 0.05.