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. 2011 Feb 2;31(5):1664–1675. doi: 10.1523/JNEUROSCI.3829-10.2011

Figure 2.

Figure 2.

GD1a/GT1b-2b mAb inhibits neurite outgrowth in various primary dissociated neuronal cultures. A, B, Embryonic DRG neurons treated with GD1a/GT1b-2b mAb have shorter neurites (B) compared with sham Ab-treated cells (A). C, D, Postnatal DRG neurons treated with GD1a/GT1b-2b mAb have shorter neurites (D) compared with sham Ab-treated cells (C). Scale bars, 50 μm. E, GD1a/GT1b-2b mAb significantly inhibits neurite outgrowth of embryonic rat DRG neurons, whereas GM1–2b and sham Abs do not inhibit neurite outgrowth. F, GD1a/GT1b-2b mAb induces dose-dependent inhibition of neurite outgrowth in rat embryonic DRG neurons. G, H, GD1a/GT1b-2b mAb inhibits the neurite outgrowth of dissociated rat primary postnatal DRG neurons (G) and spinal motor neurons (H). *p < 0.05. Control, Cultures without sham or anti-ganglioside Ab treatment.