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GD1a/GT1b-2b mAb induces inhibition of neurite outgrowth by engaging cell-surface gangliosides. A–C, Wild-type (WT) neurons treated with sham Ab have significantly longer neurites (A, C) compared with GD1a/GT1b-2b-treated group (B, C). D–F, Galgt1-null neurons treated with sham (D, F) and GD1a/GT1b-2b (E, F) Abs have similar neurite length. Scale bar, 50 μm. Control, Cultures without sham or anti-ganglioside Ab treatment.
