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. 2011 Feb 2;31(5):1664–1675. doi: 10.1523/JNEUROSCI.3829-10.2011

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Copyright © 2011 the authors 0270-6474/11/311664-12$15.00/0

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Figure 8. — GD1a/GT1b-2b mAbs inhibit neurite outgrowth through activation of RhoA and ROCK. A, DRG neurons transfected with GFP-tagged DN RhoA construct (green) are resistant to the inhibitory effects of GD1a/GT1b-2b mAb compared with nontransfected cells; transfected and nontransfected DRG neurons were identified by β-III-tubulin staining (red). Scale bar, 50 μm. B, GD1a/GT1b-2b-mediated inhibition of neurite outgrowth was significantly reversed in neurons transfected (gray bars) with DN RhoA compared with nontransfected cells (black bars); sham Ab had no effect on transfected and nontransfected cells. C, C3-transferase (RhoA inhibitor) partially reverses GD1a/GT1b-2b mAb induced inhibition, whereas Y27632 (ROCK inhibitor) completely reverses this inhibition. *p < 0.05.