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. 2011 Feb 2;31(5):1664–1675. doi: 10.1523/JNEUROSCI.3829-10.2011

Figure 9.

Figure 9.

GD1a/GT1b-2b mAb induces growth cone collapse in DRG neurons. A, B, Representative images of the growth cones of DRG neurons treated with GD1a/GT1b-2b (B) and sham Abs (A) showing growth cone collapse and loss of filopodia. Scale bar, 5 μm. C, Quantitative analysis showed that GD1a/GT1b-2b mAb-treated DRG neurons (30 min) had significant decrease in growth cone area compared with sham Ab-treated group. D, The number of filopodia/growth cone in GD1a/GT1b-2b-treated group (30 min) was significantly reduced compared with sham Ab-treated neurons. E, There was a significant increase in the number of collapsed growth cones in DRG neurons treated with GD1a/GT1b-2b mAb (overnight) compared with sham Ab or control (no Ab treatment) groups. *p < 0.05.