Figure 4.

Chronic FLX treatment during adulthood produces motor deficits. a, b, Motor behavior was evaluated using the rotarod test (a) and the clasping test (b). a, No effect of acute FLX treatment was detected on the latency to fall in a cross-sectional (box; n = 30 mice per group; 20 rpm) or longitudinal study (n = 15 mice per group; 20 rpm). Chronic FLX treatment reduced the latency to fall starting after 2 weeks of treatment, and performance normalized after cessation of FLX treatment (n = 15 mice per group; 20 rpm). b, No effect of acute FLX treatment was detected on clasping behavior (n = 5–8 mice per group). Chronic FLX treatment increased clasping behavior starting after 2 weeks of treatment, and cessation of FLX treatment reduced clasping behavior (n = 15 mice per group). *p < 0.05; **p < 0.01; ***p < 0.001.