Figure 7.

l-DOPA treatment reverses motor deficits elicited by 5-HTT blockade. a–f, Motor behavior was evaluated using the rotarod test (a–d) and the open-field test (e, f). FLX-treated mice displayed a reduced latency to fall compared to VEH-treated controls only when treated with VEH but not when treated with l-DOPA/benserazide (15/12.5 and 100/12.5 mg/kg, i.p) at 20 rpm (a) and at 30 rpm (b; n = 7–8 mice per group). 5-htt−/− mice displayed a reduced latency to fall compared to 5-htt+/+ littermates only when treated with VEH but not when treated with l-DOPA/benserazide (100/12.5 mg/kg, i.p) at 20 rpm (c) and at 30 rpm (d; n = 14–18 mice per group). e, f, l-DOPA/benserazide treatment did not affect behavior in the open-field test (n = 13–24 mice per group). *p < 0.05; **p < 0.01.