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. Author manuscript; available in PMC: 2013 Aug 31.
Published in final edited form as: Transl Cancer Res. 2013 Jun;2(3):130–143. doi: 10.3978/j.issn.2218-676X.2013.04.02

Figure 2.

Figure 2

DNA end processing. If required, a number of different processing enzymes can be utilized for making the DNA ends compatible for ligation for the terminal step of the NHEJ pathway; A. XRCC4, likely in conjunction with the Ku heterodimer, may serve as a scaffold required for the recruitment of specific DNA end processing enzymes. The XRCC4-Ku scaffold likely plays a role as a tool-belt where it can choose which enzyme is required depending on the nature of the DSB; B. Complex DNA damage may be processed via the DNA-PKcs-mediated recruitment of the nuclease Artemis and the processing of the complex damage may require ATM; C. Processing of the DNA ends makes them compatible for ligation