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Bridging of the DNA ends and promotion of end stability. A. Ku binding to the DSB protects and stabilizes the DNA ends; B. DNA-PKcs can tether DNA ends via formation of a synaptic complex; C. XRCC4 and XLF can produce a filament which can bridge the two portions of the broken DNA molecule and possibly stabilize them; D. XRCC4-XLF filament possibly in complex with DNA-PKcs and Ku to produce a tightly regulated DNA end protection complex
