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. Author manuscript; available in PMC: 2013 Aug 31.
Published in final edited form as: Transl Cancer Res. 2013 Jun;2(3):130–143. doi: 10.3978/j.issn.2218-676X.2013.04.02

Figure 4.

Figure 4

Ligation of the DNA ends and dissolution of the NHEJ complex. A. Autophosphorylation and/or phosphorylation by ATM mediate a conformational change of DNA-PKcs resulting in the opening of the pincers of DNA-PKcs resulting in its release from the DSB. It is not known if this occurs before or after the terminal ligation step; B. Ligation of the DNA ends via DNA-Ligase IV. The terminal ligation step is aided by XRCC4, XLF, and likely APLF; C. Ku is likely stuck on the DNA molecule following the ligation step. Ku may be released from the repaired DSB via ubiquitylation via either Rnf8 or the SCF complex of Skp1-Cul1-Fbx112 and results in degradation of Ku; D. The DNA DSB is repaired