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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Cell Biochem Biophys. 2013 Sep;67(1):3–13. doi: 10.1007/s12013-013-9623-7

Figure 2. Compensatory mechanisms in intracellular proteolysis.

Figure 2

Changes in the activity of one proteolytic system impact the activity of the other systems. So far, most of the changes described are of compensatory nature whereby blockage of one pathway (marked with a red cross) leads to upregulation of another one (marked with a green arrow). However, there are also instances in which blockage of one pathway also interferes with the functionality of another. This proteolytic crosstalk may be influenced by many factors, as the ones shown in the cloud.