Figure 1.
Anti-NP responses in SAP−/− and wt mice are in part determined by the genetic background. SAP−/− or wt B6 and BALB/c mice were immunized with NP-KLH using either CFA (A-C) or Alum (D-F) as adjuvant. Immune responses were followed by anti-NP IgG (A and D) and anti-NP IgM (B and E) titers in the serum, as well as by flow cytometry of the splenic GCB (B220+GL7+Fas+) cells (C and F).
Data are representative of either 2 or 3 independent experiments with 3 to 5 animals per group.