Table 2.
Cardiac allograft vasculopathy by angiography and intravascular ultrasound per patient analysis
| Variable | All (n = 53) | Group 1 (n = 6) | Group 2 (n = 19) | Group 3 (n = 28) | P-value |
|---|---|---|---|---|---|
| Coronary angiography | |||||
| CAV by angiography, n (%) | 25 (47.2) | 0 (0.0) | 8 (42.1) | 17 (60.7) | 0.023 |
| CAV ISHLT score | 0.19 | ||||
| ISHLT score 0, n (%) | 28 (52.8) | 6 (100) | 11 (57.9) | 11 (39.3) | |
| ISHLT score 1, n (%) | 19 (35.9) | 0 (0.0) | 7 (36.8) | 12 (42.9) | |
| ISHLT score 2, n (%) | 4 (7.6) | 0 (0.0) | 1 (5.3) | 3 (10.7) | |
| ISHLT score 3, n (%) | 2 (3.8) | 0 (0.0) | 0 (0.0) | 2 (7.1) | |
| IVUS | |||||
| CAV by IVUS, n (%) | 38 (71.7) | 1 (16.7) | 11 (57.9) | 26 (92.9) | <0.001 |
| MIT by IVUS, mm | 0.9 (0.0, 1.3) | 0.0 (0.0, 0.1) | 0.5 (0.0, 1.1) | 1.1 (0.7, 1.4) | <0.001 |
| Vessel volume index (mm3/mm) | 15.9 (14.2, 19.5) | 15.8 (14.9, 15.8) | 17.9 (14.4, 19.4) | 16.4 (13.8, 19.8) | 0.73 |
| Lumen volume index (mm3/mm) | 11.5 (8.6, 13.6) | 13.6 (12.6, 13.8) | 12.4 (10.1, 14.4) | 9.7 (7.0, 14.8) | 0.015 |
| Plaque volume index (mm3/mm) | 4.4 (2.1, 8.1) | 2.1 (1.8, 2.3) | 2.4 (1.9, 6.5) | 6.6 (3.8, 9.4) | 0.005 |
| Plaque burden, % | 26.6 (14.5, 45.0) | 13.0 (12.5, 14.6) | 20.9 (11.9, 32.5) | 38.3 (25.8, 49.1) | <0.001 |
CAV, cardiac allograft vasculopathy; ISHLT, International Society of Heart and Lung Transplantation; IVUS, intravascular ultrasound; MIT, maximal intimal thickness.