Table 4.
Genotype and allele frequency distribution of NRAMP1 and VDR genes in the controls and TB patients of the Chinese Kazak population.
| Genotype and allele | Tuberculosis N (Freq) |
Control N (Freq) |
χ 2 | OR (95% CI) | P |
|---|---|---|---|---|---|
| NRAMP1-3′UTR | |||||
| TGTG++ | 138 (64.8) | 167 (79.1) | 1.00 | ||
| TGTG+/del | 63 (29.6) | 41 (19.5) | 12.802 | 1.859 (1.182–2.926) | 0.002 |
| TGTGdel/del | 12 (5.6) | 3 (1.4) | 4.841 (1.339–17.499) | ||
| Alleles | |||||
| TGTG | 339 (79.6) | 375 (88.9) | 13.737 | 2.048 (1.395–3.006) | <0.001 |
| TGTGdel | 87 (20.4) | 47 (11.1) | |||
| VDR-FokI | |||||
| FF | 72 (33.8) | 101 (47.9) | 1.00 | ||
| Ff | 96 (45.1) | 88 (41.7) | 13.095 | 1.530 (1.007–2.325) | 0.001 |
| ff | 45 (21.1) | 22 (10.4) | 2.869 (1.586–5.191) | ||
| Alleles | |||||
| F | 240 (56.3) | 290 (68.7) | 13.868 | 1.703 (1.285–2.255) | <0.001 |
| f | 186 (43.7) | 132 (31.3) | |||
| VDR-TaqI | |||||
| TT | 191 (89.7) | 183 (86.7) | 1.00 | ||
| Tt | 19 (8.9) | 23 (10.9) | — | 0.791 (0.417–1.502) | 0.581 |
| tt | 3 (1.4) | 5 (2.4) | 0.575 (0.135–2.440) | ||
| Alleles | |||||
| T | 401 (94.1) | 389 (92.2) | 1.267 | 0.735 (0.429–1.259) | 0.260 |
| t | 25 (5.9) | 33 (7.8) |
Note: Genotype frequencies were compared between the patients and control subjects by χ 2 test or Fisher's exact test when appropriate. Allele frequencies were compared between the patients and control subjects by use of a χ 2 test for 2-by-2 contingency tables. N: the sample size; OR: odds ratio; 95% CI: 95% confidence interval; Freq: frequency.