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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Mol Microbiol. 2013 Jul 12;89(4):732–750. doi: 10.1111/mmi.12310

Fig. 10.

Fig. 10

Model of the regulation of opaque cell filamentation in C. albicans. A. Pathways involved in the regulation of opaque cell filamentation. Environmental cues signal the positive cAMP pathway and the negative pathway mediated by the key regulator Bcr1 to control the expression of filamentous specific genes. B. Models of separate and integrated phenotypic switching systems. Integration of the white-opaque switching and yeast-filamentous transition systems increases the complexity and plasticity of phenotypic switching in C. albicans. Solid lines represent confirmed phenotypic switches. Dashed lines represent unconfirmed switches. Wh, white cell phase; Op, opaque cell phase; Fila. wh, filamentous white cell phase; Fila. op, filamentous opaque cell phase.