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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Apr 4;33(6):1350–1359. doi: 10.1161/ATVBAHA.112.300287

Figure 3. BMPRII deficiency exacerbates atherosclerosis development in ApoE−/− mice.

Figure 3

(A) BMPRII+/−ApoE−/− (n=12) and littermate control BMPRII+/+ApoE−/− mice (n=14) were partially ligated and fed a high-fat diet for 2 weeks. Frozen sections from the ligated LCA (d-flow) and contralateral RCA (s-flow) were stained with Oil-Red-O as shown by representative microscopy images. (B) Atherosclerotic lesion area was quantified (*p<0.001). (C) BMPRII+/−ApoE−/− (n=8) and BMPRII+/+ApoE−/− mice (n=10) were fed the high-fat diet for 2 months. Aortic arch regions were stained with Oil-Red-O as shown, and (D) atherosclerotic lesion areas determined (*p<0.05).