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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Apr 4;33(6):1350–1359. doi: 10.1161/ATVBAHA.112.300287

Figure 6. Endothelial inflammation induced by BMPRII knockdown can be rescued by overexpressing BMPRII WT, but not by the BMPRII short form.

Figure 6

(A) shows a schematic of BMPRII WT and BMPRII Short-form, indicating the C-terminal FLAG tag in both constructs. (B) HUVECs treated with non.si and BRII.si were further infected with Adenoviral BMPRII WT or BMPRII Short for 24 h. Representative blots show expression of ICAM-1 and VCAM-1 with FLAG tagged BMPRII Short form and BMPRII WT expression and β-actin as controls. The bar graph shows the quantification of ICAM-1 and VCAM-1 expression of Western blots (n=3; *p<0.05). (C) The schematic shows summary and working hypothesis that pro-atherogenic conditions downregulate BMPRII expression, which in turn induces endothelial inflammation and atherosclerosis. Anti-atherogenic conditions upregulate endothelial BMPRII expression.