Table 2. Analogues Containing Disubstituted Phenyl Rings.

compd	X	R1	R2	R3	inhibition of basal ATPase activity Kiapp (nM)	LE	K562 cells GI50 (nM)
28	S	2-F	3-Me	H	293.6 ± 23.2	0.36	2547 ± 141
29	S	2-F	4-Me	H	201.3 ± 18.7	0.37	2084 ± 109
30	S	2-F	4-OMe	(R)-CO2H	10.4 ± 4.5	0.38	82 ± 3
31	S	2-F	4-OMe	H	11.6 ± 3.7	0.42	489 ± 26
32	S	3-F	4-OMe	H	162.2 ± 15.6	0.36	1892 ± 134
33	S	3-Cl	4-Cl	H	35.2 ± 4.9	0.41	1993 ± 343
34	S	3-Me	4-Me	(R)-CO2H	1.2 ± 0.1	0.43	72 ± 8
35	S	3-Me	4-Me	H	25.7 ± 6.3	0.41	729 ± 43
36	S	3-Et	4-Me	(R)-CO2H	4.6 ± 1.7	0.39	34 ± 2
37	S	3-Et	4-Me	H	7.8 ± 3.9	0.43	1045 ± 42
38	S	3,4-(CH2)4		(R)-CO2H	2.1 ± 0.5	0.40	56 ± 2
39	S	3,4-(CH2)4		H	10.6 ± 3.2	0.40	934 ± 127
40	C	2-F	4-OMe	H	37.9 ± 4.7	0.39	764 ± 42
41	C	3-Cl	4-Cl	H	31.4 ± 6.4	0.41	633 ± 126
rac-42	C	3-Me	4-Me	CO2H	12.4 ± 4.4	0.38	23.4 ± 1.8