Table 3. Analogues with Modifications on Two Phenyl Rings.

compd	X	R1	R2	R3	Inhibition of basal ATPase activity Kiapp (nM)	LE	K562 cells GI50 (nM)
8a	S	3-OH	H	H	200.3 ± 51.9	0.38	555 ± 121
43a	S	3-CN	H	H	542.4 ± 41.3	0.34	2128 ± 108
9a	S	3-CONH2	H	H	419.7 ± 38.8	0.33	802 ± 51
44	S	4-Me	4-Me	H	56.0 ± 5.0	0.40	2174 ± 119
rac-45	S	3-OH	3-Cl	H	200.3 ± 35.3	0.37	1662 ± 77
rac-46	S	3-OH	3-Et	H	4.8 ± 1.2	0.44	260 ± 19
rac-47	S	3-OH	4-Me	H	7.1 ± 1.8	0.44	98 ± 6
rac-48	S	3-CN	4-Me	H	64.2 ± 5.2	0.38	1186 ± 34
rac-49	S	3-CONH2	4-Me	H	55.6 ± 8.0	0.37	308 ± 16
dia-50	C	3-OH	4-Me	CO2H	7.8 ± 2.0	0.39	813 ± 20
rac-51	C	3-OH	4-Me	H	33.6 ± 6.4	0.41	232 ± 24

^aValues provided for reference from previous paper.²⁹