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. 2013 Feb 11;56(5):1878–1893. doi: 10.1021/jm3014597

Table 7. β-Fluorinated Analogues of 4-Methoxytriphenylbutanamine 26.

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compd R1 R2 pKa inhibition of basal ATPase activity Kiapp (nM) LE K562 cells GI50 (nM)
26 H H 9.86 ± 0.05 15.5 ± 5.3 0.43 83 ± 4
rac-52 F H 7.86 ± 0.07 27.3 ± 1.2 0.40 652 ± 61
53 F2 H 7.11 ± 0.05 88.4 ± 1.9 0.36 2624 ± 379
rac-54 H CF3 4.63 ± 0.10 2268 ± 39 0.27 >100000