Table 1.

Patient survival and presence of tumor-infiltrating lymphocyte (TIL) in primary melanoma.

	Nb of patients a	T cell infiltration b	5-year survival		Sentinel Lymp Node (SLN) d
			%	Correlation with T cell infiltrate c
Larsen, 1978 [27]	669	TIL+	78
		TIL+++	91	+	-
Johnson, 1985 [29]	262	TIL+	48
		TIL+++	60	+	-
Clark, 1989 [31]	386	TIL absent	59 e
		TIL brisk	89
		TIL non-brisk	75	+	-
Clemente, 1996 [35]	285	TIL absent	37
		TIL brisk	77
		TIL non-brisk	53	+	+f
Tuthill, 2002 [38]	259	TIL absent	71
		TIL brisk	100
		TIL non-brisk	71	+	-
Taylor, 2007 [43]	887	TIL absent	75
		TIL brisk + non-brisk	76	-	+
Mandalà, 2009 [45]	1251	TIL absent	90
		TIL brisk + non-brisk	95	+ g	+
Barnhill, 1996 [33]	650	TIL absent	86
		TIL present	90	-	-

^aOnly studies including >180 patients were considered;

^bNumber of TIL estimated by immunohistology;

^cLog-rank. “+” means significant;

^dSentinel Lymph Node (SLN) biopsy procedure included in the analysis;

^eProportion of patients with 8-year overall survival;

^fSLN⁺ excluded from the analysis;

^gNot confirmed by the multivariate Cox proportional hazard model.