Table 2.
ErbB2 orthologue restriction of the protection against tumor growth elicited by anti-ErbB2 DNA chimeric vaccines.
| Immunizing plasmid | Recipient mouse | Challenging Tumor | Autochthonous Carcinoma | ||
|---|---|---|---|---|---|
|
|
|
||||
| ErbB2 orthologue expressed | Efficacy of the protection | ErbB2 orthologue expressed | Efficacy of the protection | ||
| RHuT | Wild-type | rat | +++* | NA# | NA |
| human | +++ | NA | NA | ||
| Transgenic for rat ErbB2 | rat | +++ | rat | +++ | |
| human | +++ | NA | NA | ||
| Transgenic for human ErbB2 | rat | +++ | NA | NA | |
| human | ++ | human | +++ | ||
| HuRT | Wild-type | rat | +++ | NA | NA |
| human | +++ | NA | NA | ||
| Transgenic for rat ErbB2 | rat | - | rat | - | |
| human | +++ | NA | NA | ||
| Transgenic for human ErbB2 | rat | ++ | NA | NA | |
| human | +++ | human | +++ | ||
*
-: 0% protection;
+
: from 0% to 30% protection;
++
: from 30% to 70% protection;
+++
: from 70% to 100% protection;
#
Not applicable