. 2011 Sep 20;3(3):3661–3675. doi: 10.3390/cancers3033661

Table 2.

Functional differences between human and mouse NKT cells.

	Human	Mouse
Coreceptor expression	CD4⁺, CD8⁺, DN type-I NKT subsets	CD4⁺, DN type-I NKT cell subsets
type-I NKT cell cytokine profile	Th2 cytokines: CD4⁺ > CD4^-	Less pronounced dichotomy of type-I
type-I NKT cell cytokine profile	Th1 cytokines: CD4⁺ < CD4^-	NKT cell cytokine production
type-I NKT frequency (blood)	Blood: <0.1–1%	Blood: ∼1–2%
NKT cell distribution	Liver enriched for type-II NKT	Liver enriched for type-I NKT cells
Effects of α-GC injection	No anti-tumor response	Prevents tumor regression and metastasis
Effects of α-GC injection	No liver toxicity	Liver toxicity