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. 2011 Sep 22;3(3):3687–3713. doi: 10.3390/cancers3033687

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — Activity of cancer vaccines: relationship between vaccine immunogenicity (activity and frequency of immune cells), repeated administration and antitumor efficacy. (A) Immunization with a single vaccine dose induces a limited expansion of CTL precursors (CTLp), T helper (Th) and/or B-cell producing antibodies and the activity is limited to a short period of time; (B) A prolonged persistence of antigen in lymphoid organs - as is reached by repetitive immunization - is necessary to increase the CTLp/Th frequency and/or antibody titer; (C) A single immunization does not change the tumor growth kinetic (red) in comparison to the control group (green); (D) Repetitive immunizations are necessary for the rejection of established tumors.