Table 2.
Oxidant/antioxidant parameters as well as concentration of carboxymethyl lysine (CML) in rat retinas.
| Control | Control + PA | Diabetic | Diabetic + PA | |
|---|---|---|---|---|
| MDA, nmol/mg protein | 2.45 ± 0.16 | 2.95 ± 0.15b | 4.75 ± 0.17a | 2.95 ± 0.15b |
| GST, nmol substrat·mg protein−1·min−1 | 176 ± 31 | 151 ± 9a,b | 82 ± 13a | 151 ± 9a,b |
| GSH-Px, nmol substrat·mg protein−1·min−1 | 0.92 ± 0.17 | 0.82 ± .165b | 0.34 ± 0.09a | 0.82 ± .165b |
| Catalase, IU·mg protein−1 | 2.61 ± 0.032 | 1.45 ± 0.21a,b | 0.52 ± 0.03a | 1.45 ± 0.21a,b |
| SOD, nmol substrat·mg protein−1·min−1 | 3.53 ± 0.45 | 2.95 ± 0.75b | 1.82 ± 0.35a | 2.95 ± 0.75b |
| GSH, nmol/mg protein | 16 ± 3 | 16 ± 2.3 | 16.11 ± 2 | 16 ± 2.3 |
| CML, pg/mg protein | 3.54 ± 0.22 | 3.2 ± 0.6b | 8.81 ± 0.34a | 3.2 ± 0.6b |
Oxidative stress markers in the kidney homogenate of apoE−/mice. Mice treated either with or without STZ in presence or absence of PA. PA treatment was continued for 12 weeks after the onset of diabetes. Data shown represent mean ± SEM. a,bSignificance difference between groups.