Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The blood brain barrier (BBB) in healthy and inflamed condition. (a) Vessel, endothelium, extracellular matrix (ECM), and glia limitans are intact. Microglia cells are in a resting state. (b) In the inflammed CNS breakdown of the BBB takes places. The glia limitans is opened, and astrocytic endfeet are drawn away. Reactive microglia secrete MMPs facilitating the opening of the BBB. Invading T cells migrate from the vessel via the perivascular space (PVS) into the neuropil.
