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Structures of the nitroheterocyclic drugs used to treat T. cruzi infections and their toxic metabolites. The highlighted regions of nifurtimox and benznidazole correspond to the 5-nitrofuran and the 2-nitroimidazole groups, respectively. The structures of the toxic unsaturated open chain nitrile and glyoxal metabolites (Hall et al. 2011; Hall and Wilkinson, 2012) are shown below the corresponding drugs.
