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. Author manuscript; available in PMC: 2013 Sep 2.
Published in final edited form as: Integr Biol (Camb). 2012 Jun 6;4(8):857–862. doi: 10.1039/c2ib20061a

Fig. 7.

Fig. 7

Towards functional microvascular networks in vitro. Negative pressure shear flow (3 dyn cm−2) in the bottom channel results in interstitial flow at a rate of 35 µm s−1 and a VEGF gradient from the top channel to the bottom channel. The HUVEC-GFP cells lining the top channel invade towards the HUVEC-dsRed lined bottom channel resulting in the formation of multiple bridging segments. Solid arrow indicated direction of axial shear flow; dashed arrow indicates direction of interstitial flow. Blue gradient bar indicates VEGF gradient from the top channel to the bottom channel. Scale bar is 100 µm.