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. 2013 Jul 4;6(5):1236–1245. doi: 10.1242/dmm.012591

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Pancreas-specific gene delivery of Reg3b–Glp-1 protects mice from STZ-induced diabetes. (A) The AAV vector construct was designed to express the REG3B–GLP-1 fusion protein conjugated with the ubiquitous furin cleavage site under the control of the mRIP promoter. GLP-1 expression was confirmed by western blotting analysis with anti-GLP-1 antibody. (B) Fasting blood glucose levels of mice receiving PBS (control, n=8) or AAV9 mRIP Reg3b–Glp-1 (REG3B-GLP-1, n=8) vectors at day −12. Mice received five consecutive low-dose intraperitoneal injections of STZ at days 1–5. Error bars represent s.e.m. (C) Average group body weight of control and REG3B–GLP-1 mice. Error bars represent s.e.m.